Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell.

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors are occurring in a patient's cells.

“SRSF1 seems to be pretty central here,” Krainer says. He explains that in addition to its interaction with DDX23, the regulator protein is needed for an earlier step in spliceosome assembly.

Many molecules come and go quickly as the spliceosome assembles and does its work. With the new method, "You get the history of all the proteins that were within close range of SRSF1," Segovia says.

"SRSF1 seems to be pretty central here," Krainer says. He explains that in addition to its interaction with DDX23, the regulator protein is needed for an earlier step in spliceosome assembly.

RNA transcription is the genomic process in which a cell produces a duplicate of a gene’s DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department ...

SRSF1 also specifically binds U1 snRNA stem-loop 3 and can be recruited to the pre-mRNA via U1 snRNA, to participate in exon definition (14). Recent studies found additional connections of SRSF1 with ...