The Galej Group at EMBL Grenoble has published new structural insights into minor spliceosome function in the journal Molecular Cell.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

“SRSF1 seems to be pretty central here,” Krainer says. He explains that in addition to its interaction with DDX23, the regulator protein is needed for an earlier step in spliceosome assembly.

RNA transcription is the genomic process in which a cell produces a duplicate of a gene’s DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department ...

In conclusion, this study demonstrates that SRSF1-mediated post-transcriptional regulation is essential for homologous pairing and synapsis during the meiotic prophase I program.

SRSF1 and other splicing factors can also direct a related process called alternative splicing —the mixing and matching of different exons from one gene, which, when spliced together, give rise ...

The cancer-causing oncogene SRSF1, first discovered through its role in splicing, is now shown also to activate cell-growth arrest, or senescence. In states of ribosomal stress or overexpression ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell.

The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout the ...

The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP ...

High levels of a splicing-regulator protein called SRSF1 causes pancreatitis and jumpstarts PDAC tumor development.