“SRSF1 seems to be pretty central here,” Krainer says. He explains that in addition to its interaction with DDX23, the regulator protein is needed for an earlier step in spliceosome assembly.

Then, the splicing machinery (spliceosome) locates the exon-intron boundaries, precisely removes the ... How did you come upon splicing-regulator protein SRSF1 as your protein of interest for this ...

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...

The cancer-causing oncogene SRSF1, first discovered through its role in splicing, is now shown also to activate cell-growth arrest, or senescence. In states of ribosomal stress or overexpression ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

SRSF1 was previously shown to be an oncoprotein, i.e., a protein involved in cancer. When it is overexpressed, it can help convert normal cells into tumor cells.

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

RNA transcription is the genomic process in which a cell produces a duplicate of a gene’s DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department ...

Think of the spliceosome as an old Transformers robot — it has individual pieces that operate independently but can also come together to form a larger structure. Sometimes, such as in the case of ...

SRSF1 was required for initial homology recognition, telomere-led chromosome movement, and synaptonemal complex (SC) assembly. Moreover, SRSF1 interacted with TRA2B and U2AF2, ...