eLife8d
Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution
4um of Oligomycin, 0.5um of FCCP, 1um of Antimycin A and Rotenone were injected into the cells at different ... with an extracellular flux analyser (Seahorse Bioscience). Similar inhibitor ...
Frontiers27d
Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation
The IRE1α inhibitor, 4 μ8c (50 μM), was used 30 min before stimulation ... Stress Test Kit (Agilent); or stimulated with oligomycin (1 μM), FCCP (1 μM), and rotenone/antimycin A (0.5 μM) following the ...
thorax.bmj27d
Hospitalised older adults with community-acquired pneumonia and sepsis have dysregulated neutrophil function but preserved glycolysis
Neutrophils were treated with inhibitors of mitochondrial respiration (rotenone/anti-mycin A) followed by 160 nM phorbol 12-myristate 13-acetate (PMA) to generate a respiratory burst.30 Oxygen ...
Business Wire29d
Laekna Announces IND Approval of LAE120 (a Novel USP1 Inhibitor) for Treatment of Advanced Solid Tumors by FDA
A novel, allosteric and highly potent USP1 inhibitor, LAE120 exhibits robust tumor inhibitory activity across various xenograft models Significantly accelerated the progress of drug discovery ...
The EMBO Journal26d
MIA40 suppresses cell death induced by apoptosis-inducing factor 1
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Mitochondria harbor respiratory complexes that ...
Frontiers29d
Targeting the inflammasome in Parkinson’s disease
We will also review promising inhibitors of NLRP3 inflammasome pathway that have potential as novel PD therapeutics. Finally, we will provide a summary of current and potential in vitro and in vivo ...
gut.bmj28d
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases
Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism ...
gut.bmj11d
RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer
Objective Dysregulated cellular metabolism is a distinct hallmark of human colorectal cancer (CRC). However, metabolic programme rewiring during tumour progression has yet to be fully understood.
University of Surrey12d
Metabolomics core facility
Metabolomics, or metabonomics, refers to the measurement of metabolites (compounds with a molecular mass < 1000 daltons) in biological materials such as blood, urine, cells. In the Faculty we are able ...