Sequence variations in human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) and protease, the molecular targets of anti-retroviral drug therapy, are prime examples of genes in which ...

RNA polymerases are sloppy. A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of ...

Singh and colleagues answer questions on managing HIV in primary care.1 Several other aspects are relevant to primary care clinicians caring for people with HIV. Many people with HIV, such as men who ...

It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs ... opportunities to create cross-class combinations, for example, a product combining the components of a PI ...