Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nature Aging , 2022; DOI: 10.1038/s43587-022-00290-0 Cite This Page : ...

The U1 snRNP complex is essential in RNA splicing. Now, Peng and his team have demonstrated that the dysfunction of the U1 snRNP contributes to neurodegeneration, opening new avenues of research ...

Transcription and RNA splicing are tightly coupled in eukaryotic cells. Here, authors report the multivalent interaction between U1 snRNP and the transcription elongation complex which may allow ...

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...

Splicing twins: Unravelling the ... an essential RNA-protein complex Peer-Reviewed Publication. European ... Structure of U11 snRNP, one of the subunits of the minor spliceosome.

Pre-mRNA splicing in a subset of human short introns is governed ... site -- are bound by the splicing factors U1 snRNP, U2 snRNP, and U2AF ... length of a 79-125 nt single-stranded RNA, ...

“Alterations in RNA splicing are known to be involved in the development of certain neurodegenerative conditions, such as spinal muscular atrophy and amyotrophic lateral sclerosis. However, until now, ...

The U1 snRNP recognizes the splice site at the 5’ end, initiating the splicing process. Arabidopsis is a genus of small flowering plants belonging to the Brassicaceae or mustard family.

The transcripts in SAP30BP-depleted human cells were analyzed by a next-generation sequencer (RNA-Seq analysis), ... one component of U2 snRNP, that is essential to promote splicing. So, ...

The U1 snRNP complex is essential in RNA splicing. Now, Peng and his team have demonstrated that the dysfunction of the U1 snRNP contributes to neurodegeneration, opening new avenues of research ...