During the first step of converting genetic information into functional proteins, cells transcribe the double-stranded helix ...

A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA splicing. Two molecular control factors play a key role in splicing, the process ...

Abstract Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore ...

Building proteins RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

Splicing is the process by which cells trim away the non-essential portions, retaining only what is needed. According to the researchers, recognizing splice sites computationally is a crucial step in ...

Synopsis RNA splicing and endoplasmic reticulum (ER) proteostasis are key to the overall control of mature protein production rates; however, the interaction between these processes is not well ...

By designing gRNAs to target these specific sites, CRISPR-Cas9 can be utilized to introduce precise modifications and manipulate splicing. Following CRISPR-Cas9 treatment, RNA-Seq can be performed to ...

“These RNA-binding small molecules selectively inhibit the two steps of splicing by adopting distinctive poses at different stages of catalysis, and by preventing crucial active site ...

RNA splicing is a heavy lift, but our cells make it look easy. New research from CSHL Professor Adrian Krainer may help explain how. Krainer’s latest study reveals a previously unseen link ...