Splicing twins: Unraveling the secrets of the minor spliceosome complex Date: February 12, 2025 Source: European Molecular Biology Laboratory Summary: Human genes that encode proteins often ...

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

The major spliceosome is abundant in cells and has been extensively investigated for more than four decades. Its long-separated twin – the minor spliceosome, is much more scarce and remains enigmatic, ...

Defining where to start cutting out the introns is just the first step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

The spliceosome is a large and complex molecular machine within the cell that removes introns from pre-messenger RNA (pre-mRNA), allowing for the proper assembly of protein-coding sequences, or exons.

The spliceosome is the collection of 150 different proteins and five small RNA molecules which orchestrate the editing process, but until now, the specific roles of its numerous components were not ...

The research article, titled "Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome," represents a significant advancement in understanding the ...

“The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process ...

RNA splicing ribozymes have been shown to possess a conserved active site that can engage small molecules, opening possibilities for the control of gene expression.

Wan has contributed to the elucidation of the molecular mechanism of RNA splicing, by uncovering the atomic structures of the spliceosome. Her research has greatly advanced understanding of the ...

Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing ...