This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

The results of this work reveal how an alternative splicing mechanism regulates an essential factor for neuronal identity.

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

RNA quality control is the active process by which ribonucleic acid ... and TENT5A/C substrate mRNAs are highlighted in the paper. Proper splicing requires efficient spliceosome assembly.

Alternative RNA splicing is similar to a movie editor cutting and rearranging scenes from the same video to produce distinct versions of a film. By deciding which sequences to keep and which to ...

In a recent study, scientists from The Jackson Laboratory (JAX) and UConn Health not only show how cancer hijacks this tightly regulated splicing and rearranging of RNA but also introduce a potential ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA—a prerequisite for protein synthesis in the cell. The poorly ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to a handful of model organisms. New research by Lu et al, looks outside this ...

Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results ... we compared the score computed in the wild-type ...

Circular RNAs (circRNAs) are currently classed as non-coding RNA (ncRNA) that ... Figure 1. circRNA splicing. circRNAs are created by non-canonical splicing process known as “backsplicing.” A ...

I find that RNA polymerase is error-prone, and these errors can result in splicing defects. Furthermore, I find that differential expression of RNA polymerase subunits causes changes in RNA polymerase ...