Researchers in the Galej Group at EMBL Grenoble have provided new insights into the structure of the minor spliceosome, an essential RNA-protein complex Structure of U11 snRNP, one of the subunits of ...

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read “snurps”) – ...

In people with symptomatic FTD, synaptic and lysosomal proteins were down compared with controls, while RNA-processing spliceosome proteins were up. The degree of change in all these protein modules ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes – more than nine in ten – are ...

The scientific feat, which took more than a decade to complete, is published in the journal Science. The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different ...

A water molecule consists of two hydrogen atoms bonded to one oxygen atom (H₂O), while the formula for hemoglobin, the protein that gives blood its red color, is C₂₉₅₂H₄₆₆₄N₈₁₂O₈₃₂S₈Fe₄. The structure ...

First Spliceosome Blueprint Reveals Complex Interplay, Uncovers Drug Targets October 31, 2024 ...

Pre-mRNA splicing, executed by spliceosomes, has been extensively studied in yeast and humans, but the structural diversity of spliceosomes in other species, such as plants, remains less understood.