Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...

To maintain constant protein production, they require highly precise splicing, a function that USP39 provides. "Blocking ...

Think of the spliceosome as an old Transformers robot — it has individual pieces that operate independently but can also come together to form a larger structure. Sometimes, such as in the case of ...

To produce a protein from the gene that encodes ... by means of biochemical studies that the helicase activity of Brr2 is inhibited by a particular part of another protein of the spliceosome, Prp8.

Many important cell mechanisms are carried out and regulated by multi-protein complexes, for example, transcription and RNA processing machinery, receptor complexes and cytoskeletal structures.

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes -- more than nine in ten ...

The minor spliceosome: Researchers reveal new structural insights into an essential RNA-protein complex. In human cells, only a small proportion of the information written in genes is used to ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

"The focus of our interest was the protein RBM5, which often exhibits mutations in lung tumors," said Dr. André Mourão of the STB. "RBM5 helps to bring the spliceosome to the mRNA by binding to a ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout ...