Ophthalmology Times connects eye care professionals with surgery, imaging, gene therapy, & diagnostic advances to enhance ...

After mild Alzheimer’s disease, the problem becomes the peroxynitrite-mediated oxidation and nitration of critical receptors, transport systems, and enzymes in the brain.

A series of 3-hydroxyflavone (3-HF) ESIPT (excited-state intramolecular proton transfer) boronate-based fluorescent probes have been developed for the detection of peroxynitrite (ONOO–). The dyes are ...

Panax ginseng shows the highest effectiveness in treating Alzheimer's because it inhibits nitro-oxidative stress, scavenges peroxynitrite, and reverses part of its damage, leading to sustained ...

Peroxynitrite could induce Hair Cells (HCs) damage in vitro on mouse cochlear. Peroxynitrite eventuated HCs loss in a basal-apical gradient manner. Outer HCs were more vulnerable to peroxynitrite ...

Franco and collaborators at Oregon State, the University of Central Florida and Rollins College found that when peroxynitrite oxidizes Hsp90 – short for heat shock protein 90 – it triggers the ...

Peroxynitrite, in turn, targets the structural protein caveolin-1 to reduce the activity of TRPV4 channels. These results suggest that endothelial caveolin-1–TRPV4 channel signaling lowers pulmonary ...

Free Chlorine and Peroxynitrite Alter the Capsid Structure of Human Norovirus GII.4 and Its Capacity to Bind Histo-Blood Group Antigens ...

Keywords: virus structure, oxidant, Qβ, MS2, inactivation, cross-link, hypochlorous acid, peroxynitrite Citation: Bastin G, Loison P, Vernex-Loset L, Dupire F, Challant J, Majou D, Boudaud N, Krier G ...

Peroxynitrite is a highly reactive oxidant derived from superoxide and nitric oxide. In normal vertebrate physiology, some phagocytes deploy this oxidant as a cytotoxin against foreign pathogens. To ...

Rationale:Ceruloplasmin antioxidant function is mainly related to its ferroxidase I (FeOxI) activity, which influences iron-dependent oxidative and nitrosative radical species generation.