Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J. Clin. Invest. 100, 723–735 (1997). Article Google Scholar Oliver, F.J. et al. Resistance to endotoxic shock ...

The first effect mentioned above is to reduce OS. OS is thought to exert many harmful effects, such as inactivating nitric oxide, forming harmful peroxynitrite and perhaps, encouraging plaque rupture.

iNOS-mediated NO production and the associated production of highly reactive free radicals such as peroxynitrite has a harmful effect (Wang Y. et al., 2020). Therefore, inhibiting NO may be a useful ...

A more detailed mechanistic study was attempted including determination of ROS and reactive nitrogen species (RNS, e.g., peroxynitrite) production and the catalase and peroxidase activities were ...

We hypothesise that NO is trapped in the epithelial lining fluid (ELF) of the normal human respiratory tract in bioequivalent forms such as S-nitrosothiols or peroxynitrite and that this trapping ...

Asthma is one of the major growth areas in therapeutics and many new drugs are currently in development. These drugs include improvements of existing classes of drugs, notably once-daily inhaled ...

Nitric oxide is endogenously released in the airways by nitric oxide synthase. Functionally, two isoforms of this enzyme exist: constitutive and inducible. The former seems to protect airways from ...

State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China ...

Laboratoire de Physique et Chimie de l’Environnement et de l’Espace (LPC2E), CNRS−Université Orléans−CNES, Orléans Cedex 2 45071, France ...