Bayer BAYRY announced a licensing agreement with Suzhou Puhe BioPharma Co., a clinical-stage biotechnology company.Suzhou Puhe BioPharma is focused on the research and development of innovative ...

New protein arginine N-methyltransferase 5 (PRMT5) inhibitors are detailed in a Scinnohub Pharmaceutical Co. Ltd. patent and described as potentially useful for the treatment of cancer.

Researchers have uncovered a promising therapeutic target for adenoid cystic carcinoma (ACC), a rare cancer of the salivary ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

Scientists at Jiangsu Hengrui Medicine Co. Ltd. and Shanghai Hengrui Pharmaceutical Co. Ltd. have synthesized protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the ...

“We are starting 2025 with momentum in TNG462, our lead PRMT5 program, with fulsome data focused on pancreatic and lung cancer expected before the end of the year,” said Barbara ...

1Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology, McGill University, Montréal, QC, Canada, ...

Department of Pathology and Laboratory Medicine (S.L., Z.W., L.Z., X.Z., X.L.Z.) and Institute of Reproductive Medicine and Developmental Sciences (S.L., L.Z., X.Z ...

methylcaller METHYLCALLER Used methylation caller. It must be either bismark or dorado (default: bismark) -p SPLIT_RATIO, --split_ratio SPLIT_RATIO the ratio between train and test dataset (default: 0 ...

Arginine methylation is mediated by protein arginine methyltransferases (PRMTs), which utilize S-adenosyl methionine as a methyl donor to catalyze mono- and dimethylation of the guanidino group of ...