You may have heard of the fantastic-sounding "dark side of the genome." This poorly studied fraction of DNA, known as ...

Researchers at the Francis Crick Institute have demonstrated that a genetic method called "pooled prime editing" can screen ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Ring-shaped extrachromosomal DNA is implicated in many cancers. Rachel Brazil talks to the scientists trying to uncover their ...

Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes in relation to viral protein HBx. GA, UNITED STA ...

Men who experienced abuse or neglect in childhood show distinct changes in the molecular makeup of their sperm, according to ...

This article explores 6-base genome sequencing and how it is empowering researchers to expand their studies to include both genetic and epigenetic data.

It’s time to shine a light on the next wave of drug discovery.

Key epigenetic mechanisms—such as DNA methylation, histone modifications, and the involvement of noncoding RNAs—regulate cccDNA activity. For example, DNA methylation suppresses viral transcription, ...

But a team of researchers led by Kishore Guda, associate professor at the Digestive Health Research Institute at the Case Western Reserve School of Medicine, found a special class of ribonucleic acid ...

Researchers at Case Western Reserve University have discovered molecules that present the potential to drive the development of gastric cancer-among the world's deadliest forms of the disease.

The main function of RNA is to convert genetic information from DNA into proteins. Non-coding RNA molecules don't carry genetic information that would later be converted to proteins. "We discovered ...