Researchers say findings suggest it may be possible to stop cancer growth using approaches such as restraining TE activity in ...

Ring-shaped extrachromosomal DNA is implicated in many cancers. Rachel Brazil talks to the scientists trying to uncover their ...

Additionally, mutations in noncoding DNA may also have functional consequences. Although these noncoding regions are often overlooked as they can be inaccessible or difficult to connect to a ...

You may have heard of the fantastic-sounding "dark side of the genome." This poorly studied fraction of DNA, known as ...

Swiss start-up Haya Therapeutics has formed a partnership with Eli Lilly – worth up to $1 billion – to look for new therapies for obesity in non-coding DNA. The biotech focuses on trawling the ...

It’s time to shine a light on the next wave of drug discovery.

Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes in relation to viral protein HBx. GA, UNITED STA ...

Researchers at the Francis Crick Institute have demonstrated that a genetic method called "pooled prime editing" can screen ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

Key epigenetic mechanisms—such as DNA methylation, histone modifications, and the involvement of noncoding RNAs—regulate cccDNA activity. For example, DNA methylation suppresses viral transcription, ...