Myeloid deficiency of the mitochondrial transacetylase tafazzin upregulates mtROS, disrupting UPR and calcium homeostasis, ...

Recent studies have highlighted the functional capacity of neutrophils as powerful mediators of tissue inflammation. Granule-packaged proteases and reactive oxygen intermediates, which are ...

Most-abundant zymogen granule proteins. ‡ Different isoforms present in zymogen granules. § Validated by morphological studies after identification by mass spectrometry. As the molecular ...

Neutrophils are major players in innate immune system. Here, we aimed to explore the heterogeneity and pro-tumour mechanisms of neutrophils in PDAC. Design We analysed single-cell transcriptomes of ...

Conclusions These data reveal a novel neutrophil-intrinsic role for Card9 in arthritogenic Th17 responses and AS pathogenesis. These data provide valuable utility in our future understanding of ...

University of California, Berkeley─University of California, San Francisco Graduate Program in Bioengineering, San Francisco, California 94158, United States Department of Bioengineering and ...

Granules India's net profit declined 6.4% to ₹117.6 crore compared to ₹125.6 crore in the same quarter last year. Revenue dropped 1.5% to ₹1,137.6 crore, down from ₹1,156 crore a year ago. Meanwhile, ...

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan ...

Neutrophils are innate immune cells that have a vital role ... As this DNA mingles with cellular components including the histones, granules and cytoplasmic proteins, the process culminates in the ...

These granules primarily consist of lysosomes containing rich enzymes, such as myeloperoxidase (MPO) and neutrophil elastase (NE), which play crucial roles in the phagocytic functions of neutrophils.