In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") -- and about 150 proteins, involved in different stages of ...

The Galej Group at EMBL Grenoble has provided new insights into minor spliceosome function, ... The major spliceosome consists of five subunits, U1, U2, U4, U6, ...

When minor spliceosome activity is reduced, the minor introns are retained in the mRNA while the major introns are spliced out. This signals the mRNA for degradation, limiting the expression of ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

About 99 percent of genes contain only introns of the “major” class ... Ohio, and colleagues was titled, "Mutations in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental ...

It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout the splicing process. Think of the spliceosome as an old ...

Researchers explored the role of the minor intron-containing gene (MIG)-encoded proteins (MIG-Ps) depending on minor spliceosome-MiG excision to be expressed in infections by pathogenic viruses.

Understanding mechanisms, disease associations and general significance of the minor spliceosome We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...