Denali Therapeutics: Vast Pipeline, First Approval Up Ahead
Despite past failures, Denali's extensive pipeline and solid financial runway make it a compelling buy at current low stock ...
JAK inhibitor combo therapy shows promise for myelofibrosis treatment in phase 3 trial
Researchers at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai have demonstrated the potential for a new combination therapy to improve outcomes for patients with ...
Pathos AI Doses First Patient in Phase 1b/2a Clinical Trial of Pocenbrodib, a CBP/p300 Inhibitor
"The clinical promise of pocenbrodib, our potential best-in-class CBP/p300 inhibitor, lies not only in its remarkable efficacy in resistant prostate cancer models, but also in our sophisticated ...
C&EN15d
Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor
Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy ...
C&EN16d
Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors
Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan ...
News Medical21d
New insights into coumarin-based MAO inhibitors for neurodegenerative diseases
Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but ... significantly enhanced MAO-B inhibition and increased selectivity for MAO ...
EurekAlert!21d
Coumarin derivatives as inhibitors against monoamine oxidase: Structure-activity relationships and inhibitory mechanisms
Understanding the structure-activity relationship (SAR) and mechanisms underlying MAO inhibitors is crucial but ... significantly enhanced MAO-B inhibition and increased selectivity for MAO ...
scienceopen.com21d
Coumarin derivatives as inhibitors against monoamine oxidase: structure-activity relationships and inhibitory mechanisms
Measure fluorescence values were determined using a microplate reader. Toloxatone and selegiline were used as positive inhibitors for MAO-A and MAO-B, respectively. The MAO-A and MAO-B inhibition ...
Business Insider29d
VYNE Therapeutics Initiates Phase 1b Trial of VYN202, a Novel BD2-Selective Oral BET Inhibitor, in Plaque Psoriasis
VYN202 is an oral small molecule BD2-selective bromodomain and extra-terminal domain (BET) inhibitor that is being ... including T cells and B cells, and subsequent inflammatory and fibrotic ...