Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...

Use precise geolocation data and actively scan device characteristics for identification. This is done to store and access information on a device and to provide personalised ads and content, ad and ...

we then binned Enzyme Commission numbers based on the primary digit in the identifier, which specifies the EC as an oxidoreductase (EC 1), transferase (EC 2), hydrolase (EC 3), lyase (EC 4), isomerase ...

Parkin, an E3 ubiquitin ligase, is recruited to the outer mitochondrial ... between wild-type and double knockouts. TCA cycle enzyme activities and mitochondrial respiration rates remained ...

This labelling process requires three types of enzymes working in sequence. E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure ...

Lac directly binds the E3 ligase STUB1, leading to increased polyubiquitination and proteasomal degradation of RUNX1. Lac inhibits Tregs activity and promotes antitumor immunity in a mouse primary ...