Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

They succeeded once they were able to isolate the splicing complexes of the fungus that were in the midst of quality control ...

First, a precursor mRNA (pre-mRNA) is formed that contains both coding information for the protein (exons) as well as non-coding segments (introns). The introns need to be cut out of the pre-mRNA ...

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Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

While the patients had the typical Dravet phenotype, the variants were not in typical regions of the SCN1A gene, as they were found in the introns rather than the exons. "We think of exons as the ...

Non-viral intron knock-ins for incorporating synthetic exons into endogenous introns enable efficient gene targeting and selective gene knockout in successfully edited cells. Proper splicing ...

The dotted lines correspond to FC values of 1.5 and -1.5 and -log10 (p-value) of 1.3. Significantly regulated exons (FC 1.5 and p-value <0.05) are shown in red. A. Metagene coverage plots of CLIP ...