the 3′ end of the intron is brought into proximity, cut, and joined to the 5′ end. This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon attacks the ph ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

The vast majority of introns are removed by the major spliceosome ... 3'-OH of the upstream exon attacks the 3' splice site phosphodiester to liberate the lariat intron and join (ligate) the ...

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells remove ...

The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows) in a two-step process (green arrows labeled 1 and 2) that splice the exons together and removes the intron ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

Surprisingly, when spliceosome components were depleted or ... We propose that this is because cross-exon interactions are not easily replaced with cross-intron interactions, thereby causing ...

RNA splicing is crucial for gene expression. After DNA is copied into messenger RNA (mRNA), noncoding parts called introns are removed, and the coding parts are spliced together.