Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

If I trained a model to predict a good intron [using] data that is already in nature, we wouldn’t get good rules,” she explained. That meant that “we had to make the data ourselves.” ...

Their OGT intron 4 reporter reliably responds to O-GlcNAc levels, mirroring the endogenous splicing event. Through a genome-wide CRISPR knockout library, they uncover a range of splicing-related genes ...

Splicing is the process by which cells trim away the non-essential portions, retaining only what is needed. According to the researchers, recognizing splice sites computationally is a crucial step in ...

The authors show that after the spliceosome is finished splicing the mRNA, it remains active and can engage in further reactions with the removed introns. This discovery provides the strongest ...

The researchers of this study utilized a cryo-EM reconstruction to show how TSEN interacts with pre-tRNA, which has an L-shaped structure, to excise an intron from the long portion of the L. “First, ...

The Bradley lab was interested in charting new territory by now searching for recursive splice sites in shorter intron regions within human genes. Due to the connection between long introns and ...

June 11, 2023 Highlights Increased minor spliceosome activity is associated with prostate cancer progression Minor intron-containing genes are overrepresented as direct interactors with oncogenes ...

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