eLife3y
Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation
Protein arginine methyltransferases (PRMTs) are required for the regulation of RNA processing factors. Type I PRMT enzymes catalyze mono- and asymmetric dimethylation; Type II enzymes catalyze mono- ...
eLife4y
The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals
Moreover, SFPQ depletion leads to increased intron retention with concomitant induction of cryptic splicing, premature transcription termination, and polyadenylation, particularly prevalent for long ...