Collaborative research led by investigators at Dana-Farber/Boston Children's Cancer and Blood Disorders Center defines a ...

Researchers harness the power of the world’s most advanced supercomputers to simulate the inner workings of cellular ...

by generating lethal DNA breaks during by transcription-coupled NER. Selection of Et743-resistant cell lines We generated two Et743-resistant derivatives of human colon carcinoma cells.

Ultimately, choosing a transcription service comes down to cost, whether it is a human or computer doing the transcribing, and the other integrated services. With the basics laid out, here are the ...

This month's cover highlights the article Natural variations of adolescent neurogenesis and anxiety predict the hierarchical status of adult inbred mice by Nicolas Toni, Thomas Larrieu and colleagues.

One of the biggest paradoxes in biology is that human genome is roughly 2 m long ... 2022). Raising the level of transcription is expected to increase the level of supercoiling generated and, ...

Instead, long-lasting epigenetic differences between trained and non-trained cells are always coupled with changes in transcription factor (TF) activity, emphasizing the central role played by TFs, ...

Dynamic regulation of transcription is crucial for the cellular responses ... yet its cellular functions and regulatory circuits remain unclear. Here, we show that human GDOWN1 strictly localizes in ...

Transcription-coupled repair (TCR) is a sub-pathway of nucleotide excision repair (NER) that preferentially removes lesions from the template-strand (t-strand) that stall RNA polymerase (RNAP) ...