A team led by Professor Kazuhiro Maeshima of the National Institute of Genetics (ROIS) and SOKENDAI in Japan has developed a ...

Chromatin is a flexibly joined chain of nucleosomes that exists inside the ... The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo ...

The amount of MNase used for each reaction was batch adjusted to obtain mono-nucleosomes after a 20 min digestion. After centrifugation at 13000 rpm for 15 min at 4C, the supernatant containing the ...

We focused on gene regulatory mechanisms controlled by DNA methylation, histones and non-coding RNAs including microRNAs, circRNAs and long non-coding RNAs. We also discuss the current challenges ...

The “Histones and Chromatin” Review series published in EMBO Reports and The EMBO Journal includes six reviews centered around the histone code hypothesis. The reviews focus on histone variants and ...

They successfully generated the HBV minichromosome for the first time, using their capabilities in reconstituting viral DNA in complex with human histones — which are ... into DNA-histone complexes ...