Researchers at the University of California, Santa Cruz, have discovered a type of gene regulation never before observed in mammals–a “ribozyme” that controls the activity of an important family of ...

Researchers have discovered a type of gene regulation never before observed in mammals -- a "ribozyme" that controls the activity of an important family of genes in several different species.

In the new experiment, researchers built their logic gates using a type of catalytic RNA called a "hammerhead ribozyme." Image: UCSB chemistry.

An intermolecular ribozyme–substrate crosslink The hammerhead consists of three helices of arbitrary sequence and length that intersect at a 15-nucleotide catalytic core.

The synthesized hammerhead ribozyme had catalytic activity, as it was able to cleave an RNA substrate at the expected location in the sequence.

The evolution involved synthesis of a specific hammerhead ribozyme structure, and successful ribozymes were repeatedly tested in successively shortened synthesis durations to select for the most ...

Scientists have obtained a near-atomic resolution image of the three-dimensional shape of the hammerhead ribozyme. The results show a ribozyme structure in which the atoms are uniquely arranged ...

Abbreviations: HHRz, hammerhead ribozyme; NEP, nuclear-encoded polymerase. SOURCE: “Viroids, survivors from the RNA world?” FLORES ET AL. 2014 ...

The scientists started with a hammerhead ribozyme called N107 that had been used as an RNA switch in prior studies, but they found that the difference in production of a transgene-encoded test protein ...

The hammerhead ribozyme has been the subject of intensive investigations by researchers around the world, and Scott found his most cherished accomplishments called into question.

Researchers at the University of California, Santa Cruz, have discovered a type of gene regulation never before observed in mammals -- a "ribozyme" that controls the activity of an important ...