Conclusions —Chimeric hammerhead ribozyme to PCNA inhibits smooth muscle cell proliferation in vitro and reduces both histomorphometric and angiographic restenosis in the porcine coronary stent model ...

The next iteration combined those ON-riboswitches with similar hammerhead ribozyme ON-riboswitches that responded to small molecules to regulate protein-ligand expression.

Filmmakers have captured hundreds of hammerhead sharks circling a volcanic island off Costa Rica for a new Netflix wildlife series.

While earlier RNA polymerase ribozymes could perform the top reaction to some extent, ribozyme 71-89 performs the full replication cycle with high fidelity. (B and C) Starting from the hammerhead ...

If the RNA polymerase ribozyme could complete a full replication cycle of not only the hammerhead ribozyme, but of its own sequence, the system will meet a widely accepted definition of life as a ...

“This is an important opportunity for us to continue work to realize potential in RNA therapeutics with our recent ribozyme discoveries,” Sullivan says. “With our technology platform, we are now in a ...

John “Jack” M. Sullivan, MD, PhD, professor of ophthalmology in the Jacobs School of Medicine and Biomedical Sciences, has been awarded a four-year National Eye Institute ...

The polerovirus virusoids, on the other hand, have a hammerhead ribozyme but it is blocked in the unit-length RNA; only when the RNA has been copied into a long oligomeric chain does it become ...

Abbreviations: HHRz, hammerhead ribozyme; NEP, nuclear-encoded polymerase. SOURCE: “Viroids, survivors from the RNA world?” FLORES ET AL. 2014 ...

The PCN1 ribozyme was capable of cleaving both human and porcine targets with equal efficiency. We created a chimeric RNA/DNA hammerhead PCN1 ribozyme in which the RNA bases of the substrate binding ...

Some of the synthetic ribozymes that have been prepared have unique structures, while others resemble the naturally occurring hammerhead ribozyme. Further examples of ribozymes include the hairpin ...