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Transgenic worm in which the splicing factor UNC-75, marked with the fluorophore mScarlet, reveals its expression throughout the nervous system. The worm was generated using CRISPR-Cas9 gene editing ...

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation, with mis-splicing linked to numerous diseases. In this webinar, Dr. Megan L Noonan will ...

The results of this work reveal how an alternative splicing mechanism regulates an essential factor for neuronal identity.

This produces the mature mRNA that contains the instructions for making a protein for a specific gene. Because incorrect RNA splicing can result in dysfunctional or overactive proteins ...