Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

The extraordinary synteny of insulin genes from zebrafish to human substantiates the key importance of the insulin hormone product. Comparison of insulin promoters spanning 450 million years of ...

The numbers of the principal regulatory elements present in insulin promoters are listed. Given the complexity and uncertainty of predicting the transcriptional outcome of mutations within ...