Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription and translation processes.

Eukaryotes genes are regulated by transcription factors (a type of protein) which bind to a region known as the promoter region found just before the gene they regulate.

We did a comparative analysis for the sequence structures and characteristics of the ribosomal protein (RP) genes in fruitfly, mouse and human. The results show that the sequence structures of RP ...

Epigenetics involves a series of biological processes that regulate chromatin-mediated DNA templates. 2 Cancer is a ...

Efficient human promoter feature extraction is still a major challenge in genome analysis as it can better understand human gene regulation and will be useful for experimental guidance. Although many ...

This article describes the three types of RNA polymerase (RNAP), the enzyme responsible for transcription in eukaryotic cells.

Ribosomal RNA synthesis is the eukaryotic cell's main transcriptional activity, but little is known about the chromatin domain organization and epigenetics of actively transcribed rRNA genes. Here, we ...

Bidirectional promoter activity, which is inherent to the promoters of selection cassettes used for genome editing, causes divergent transcription that can disrupt expression of genes neighboring ...

Controlled genes are expressed from a strong semisynthetic promoter repressed by the prokaryotic TetR, which also represses its own synthesis; with basal expression abolished by a second, 'zeroing' ...