This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

A deep-learning model trained on human data reveals that promoter mutations may explain a significant portion of unsolved ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

Computational analysis of the insulin promoters for novel evolutionary conserved sequences uncovered a single short region immediately upstream of the A3 box (see ABOXES); however, this region ...

Implications Investigations based on rodents and their insulin genes have provided invaluable insights into diabetes and the workings of insulin promoters.

A research team at KAIST has identified the core gene expression networks regulated by key proteins ... by inositol metabolism enzymes serve as vital secondary messengers in eukaryotic cell signaling ...

Transcriptional regulatory elements are nucleotide sequences of a gene that are involved in regulation of genetic transcription. These include the promoter, plus response elements, activator and ...