eLife5d
Generative modeling for RNA splicing predictions and design
Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...
Frontiers21d
Computational Tools for Splicing Defect Prediction in Breast/Ovarian Cancer Genes: How Efficient Are They at Predicting RNA Alterations?
In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in ...
Phys.org1mon
Biologists discover a new type of control over RNA splicing
RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns ...
GitHub1y
splice-junctions
Add a description, image, and links to the splice-junctions topic page so that developers can more easily learn about it.
Frontiers2y
Genome-wide identification of alternative splicing associated with histone deacetylase inhibitor in cutaneous T-cell lymphomas
The differential AS events (resistant AS, RAS) between the sensitive and resistant groups before treatment were analyzed and obtained. Variable splicing events with significant differences between the ...
eLife9y
RNA polymerase errors cause splicing defects and can be regulated by differential expression of RNA polymerase subunits
I find that RNA polymerase is error-prone, and these errors can result in splicing defects. Furthermore, I find that differential expression of RNA polymerase subunits causes changes in RNA polymerase ...