We characterized back-splicing cis- and trans-elements, and found viral circRNAs resistant to spliceosome perturbation and lacking canonical splice donor-acceptors. Subsequent loss-of-function studies ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Plant arbovirus infection is regulated by a ...

1 The importance of these processes in the pathogenesis of TDP-43 proteinopathies requires further clarification. Cytoplasmic aggregation of TDP-43 has also been demonstrated in glial cells,47 48 ...

GENETIC researchers in Barcelona have reached a historic milestone, creating the very first map of the spliceosome. A key part of interpreting DNA, the spliceosome helps cells to interpret and ...

Here, we show that human GDOWN1 strictly localizes in the cytoplasm of various types of somatic cells and exhibits a potent resistance to the imposed driving force for its nuclear localization.

The spliceosome must identify the correct splice sites (SS) and branchsite (BS) used during splicing. E complex is the earliest spliceosome precursor in which the 5' SS and BS are defined. Definition ...