This process is essential for maintaining cell health and functionality by enabling ... which plays a vital role in regulating endosome maturation. This gene encodes a deubiquitinating enzyme ...

Unfortunately, even when LNPs reach their target cells, the nanoparticles are typically ... that change their charge to help them escape the endosome. These lipids are not commercially available ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

outside the cell, draws the contents in, and forms an intracellular vesicle called an endosome. This vesicle travels through the cell, and its contents are digested as it merges with vesicles ...

Caption After binding of the toxin to as yet unknown receptors on the surface of the host cell, the toxin is endocytosed. Acidification of the endosome triggers a conformational change inside the ...