Nature3d
Single-molecule biophysics articles from across Nature Portfolio
Single-molecule biophysics is the study of the dynamics and interactions of individual biomolecules to understand how they carry out their functions in living cells. For example, monitoring the ...
The EMBO Journal12d
Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Glioblastomas (GBM) are treated with high ...
Nature19d
A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis
The result is a three-dimensional Fourier, or electron-density, map of the unit cell, which for the first time reveals the general nature of the tertiary structure of a protein molecule.
FierceBiotech22d
Takeda fronts $46M for 2nd small molecule collab with BridGene
Takeda has returned to BridGene Biosciences for another small-molecule collaboration—this time focused on immunology as well as neurology. BridGene’s pursuit of undruggable targets is enabled ...
C&EN25d
Predicting Antimicrobial Class Specificity of Small Molecules Using Machine Learning
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Schnackenburgallee 114, Hamburg 22525, Germany Bonn-Aachen International Center for Information Technology (B-IT), University ...
C&EN1mon
Single-Molecule Amplification-Free Detection of Nucleic Acid Biomarkers from Body Fluids via an Optical Microfiber with a Nanointerface
Department of Neurology and Stroke Center, The first Affiliated Hospital & Clinical Neuroscience Institute, Key Lab of Basic and Translational Research of Pan-vascular Diseases, Jinan University, ...
Life on Earth Depends on Networks of Ocean Bacteria
Nanotube bridge networks grow between the most abundant photosynthetic bacteria in the oceans, suggesting that the world is ...
Cancer Research1mon
HPV and p53 Status as Precision Determinants of Head and Neck Cancer Response to DNA-PKcs Inhibition in Combination with Irradiation
1Department of Radiation Oncology, Inselspital Bern University Hospital, Bern, Switzerland. 2Department for BioMedical Research, Radiation Oncology, University of Bern, Bern, Switzerland. 3Graduate ...
Frontiers3y
The Optimal Lipid Chain Length of a Membrane-Permeabilizing Lipopeptide Results From the Balance of Membrane Partitioning and Local Damage
Calcein and ethylenediaminetetraacetic acid (EDTA ... are unaffected by a slow redistribution of the molecule after heterogeneously binding to liposomes upon mixing. The finding of a significant lag ...
eLife3y
The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model
Aggregation of Cu–Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). Although more than 140 disease mutations of SOD1 are available, their ...
eLife5y
Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane
Mitochondrial membrane dynamics is a cellular rheostat that relates metabolic function and organelle morphology. Using an in vitro reconstitution system, we describe a mechanism for how mitochondrial ...