At early-stage cholestasis, most canalicular transporters and sinusoidal uptake transporters were downregulated, including bile salt export pump (BSEP, ABCB11), multidrug resistant protein 3 (MDR3 ...

2010;30(2):147-159. Taken together, many drugs as well as endogenous steroid metabolites have the potential to interfere with transport activity of BSEP. As this includes direct and indirect ...

[1] The discoveries that mutations in several bile export pumps (MDR3, BSEP) result in progressive familial intrahepatic cholestasis have provided dramatic proof of the important role that these ...

Protein mass and mRNA of the Na + /taurocholate cotransporting polypeptide (Ntcp), the bile salt export pump (Bsep), and the multidrug resistant ... and molecular alterations consistent with mild ...

These cytokines also mediate damage to hepatocyte bile transport system (NTCP; OATP; BSEP; MRP2), which disrupts tight junctions ... with bile flow defects further exacerbating cholestasis. TNF-α, ...

- 2024 net product sales of approximately $336 million exceeds upper end of guidance range; preliminary and unaudited estimate - 2025 expected global net product sales of $420 million to $435 ...

Buy BSEP near 42.99 target 43.76 stop loss @ 42.87 Details The technical summary data tells us to buy BSEP near 42.99 with an upside target of 43.76. This data also tells us to set a stop loss @ 42.87 ...

The HPA axis dysfunctions were extensively studied in neuroendocrine disorders such as depression and chronic fatigue syndrome but less so in hepatic cholestasis, cirrhosis or other liver diseases.

It is also approved in the U.S. for the treatment of cholestatic pruritus in patients with progressive familial intrahepatic cholestasis (PFIC) 12 months of age and older and in Europe for the ...

Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and ...

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VCSH Vanguard Short-Term Corporate Bond Index Fund ETF Shares ...