Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

In this study, we unveil a common mechanism underlying these observations for the DNA-scaffolded enzymes that acts on enzymes independent of their catalytic mechanisms. By testing a variety of ...

Researchers at Utah State University (USU) are investigating ways to reduce per- and polyfluoroalkyl substances (PFAS) in biosolids. Specifically, the Utah Water Research Laboratory (UWRL) is ...

Oral substrate reduction therapy (SRT) with eliglustat offers a potential alternative, particularly for those with barriers to enzyme replacement therapy (ERT). Objective: Evaluate the safety and ...

As Elon Musk and his Department of Government Efficiency (DOGE) take a chainsaw to federal agencies and funding, critical research—including that related to overdose, harm reduction and other drug ...

These enzymes are capable of degrading a wide range of xenobiotics and complex dyes, such as lignin and azo dyes, anthraquinone ... have advanced the development of technologies that aim to reduce ...

After more than 1 year of treatment with CNB, close monitoring and management of drug–drug interactions may reduce enzyme-inducing ASMs and lead to better long-term outcomes. With CNB treatment, many ...

The progenitor of the scaffolding protein was actually an enzyme, but the evolution of its spindle-orienting ability can be recapitulated by introducing a single amino acid change that happened many ...