This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. Alternative RNA splicing functions ...

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Overriding the "Off Switch" Cells function through an intricate network of proteins, each designed for specific tasks like ...

A study reveals how cancer disrupts RNA splicing and presents a potential therapy using antisense oligonucleotides to target ...

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different ...

Dyne Therapeutics’ DYNE-101 shows positive results in phase 1/2 ACHIEVE study. Read why DYN stock may rise with FDA approval and a $2.78B market opportunity.

And then with regard to other types of therapies like siRNA, ASO, RNA editing, our key focus is on ensuring that we allow CRISPR or use CRISPR to do things that others cannot, that those cannot do.

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to a handful of model organisms. New research by Lu et al, looks outside this ...

use an antisense oligonucleotide (ASO ... RNA targets in a sequence-specific manner, leading to RNAse-mediated target degradation. Bunting et al. began by screening 230 ASOs targeting MSH3 mRNA ...