Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms.

A study reveals how cancer disrupts RNA splicing and presents a potential therapy using antisense oligonucleotides to target ...

RNA splicing is the process by which cells remove certain portions of messenger RNA (mRNA) molecules. This produces the mature mRNA that contains the instructions for making a protein for a ...

to degrade messenger RNA (mRNA) containing the same sequence as the dsRNA. The process occurs in at least two steps: an endogenous ribonuclease cleaves the longer dsRNA into shorter, 21- or ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

Fire and Mello were awarded the Nobel Prize in Physiology or Medicine in 2006 for their work on RNAi. siRNAs are 21-25 nucleotide dsRNA molecules that are perfectly complementary to their target mRNA.

(Image: ttsz/iStock via Getty Images Plus) The Role of mRNA in Gene Expression Messenger RNA is an essential component of the gene expression process, which involves the conversion of genetic ...