Experiments have shown that this is caused by a mutated tRNA which carries a single base change in its anticodon. This allows it to read the chain-terminating codon as if it spelt tyrosine.

strict codon filter -t TRN, --trn TRN Path to trna-codon table (NCBI format) -f FILTER_THRESHOLD, --filter_threshold FILTER_THRESHOLD Bit-score filter: set the filter threshold python ...

Aminoacyl tRNA synthetases (aaRS), enzymes that catalyze the attachment of each amino acid to its cognate tRNA, are such proteins that have acquired new domains and motifs that enable non-canonical ...

Laboratory for Chemical Synthetic Biology and Xenobiology, Department of Chemistry, University of Manitoba, 144 Dysart Rd, R3T2N2 Winnipeg, MB, Canada ...