We focused on the U1 snRNP U1C protein because it is important in both mammalian and yeast splicing 13,14,15,16 and crosslinking data indicate that U1C associates directly with the 5′ splice site 8.

The U1 snRNP complex ensures that the protein blueprints are fully completed. This is important because cells tend to halt ...

Several protein kinases, including SRPK1 and SRPK2, have been implicated in spliceosome assembly and catalytic activation. However, little is known about their targets. Here we show that SRPK1 is ...

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research , 2021; 49 (10): 5845 DOI: 10.1093/nar/gkab386 Cite This Page : ...

U1 Adaptors are bivalent oligonucleotides that engage sequence-specific mRNA and the U1 small nuclear ribonuclear protein (U1 snRNP), which is a ubiquitous intracellular machine that regulates ...

Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nature Aging , 2022; DOI: 10.1038/s43587-022-00290-0 Cite This Page : ...

Effects of U1 snRNP reduction (IMAGE) Martin-Luther-Universität Halle-Wittenberg. Caption ... /Life sciences/Biochemistry/Protein functions/Protein analysis/ Protein complexes ...