Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nature Aging, 2022; DOI: 10.1038/s43587-022-00290-0 ...

The analysis of the structure of U1 snRNP (Pomeranz Krummel et al, 2009; Kondo et al, 2015) and the sequence of the U1 snRNA revealed that stem‐loop 3, which is solvent accessible and free of any ...

As a pivotal regulator of 5’ splice site recognition, U1 small nuclear ribonucleoprotein (U1 snRNP)-specific protein C (U1C) regulates pre-mRNA splicing by interacting with other components of the U1 ...

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research, 2021; 49 (10): 5845 DOI: 10.1093/nar/gkab386 ...

PRPF8 is the only U5 snRNP protein where recurrent somatic mutations have been linked to cancer, joining the ranks of spliceosome factors such as U2AF1 and SF3B1 as frequently mutated in certain types ...

Deposition and dysfunction of U1 small nuclear ribonucleoprotein (snRNP) have been revealed in Alzheimer’s disease (AD), but whether U1 is involved in the amyloid precursor protein (APP) and Tau ...

RNA helicases can remodel substrate RNA–protein complexes in diverse ways. However, these activities have typically been studied using noncognate helicase-substrate systems, because the in vivo ...

Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses ...

U1 snRNP binds to the 5′ exon-intron junction of pre-mRNA and thus plays a crucial role at an early stage of pre-mRNA splicing. We present two crystal structures of engineered U1 sub-structures, which ...

Drosophila SNF is a member of the U1A/U2B″/SNF protein family that is found in U1 and U2 snRNPs, where it binds to Stemloop II and Stemloop IV of U1 and U2 snRNA, respectively. SNF also binds to the ...