In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process.

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching Gene Pieces Together ...

In this new study, the researchers reveal the structure of U11 snRNP -- one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

image: Structure of U11 snRNP, one of the subunits of the minor spliceosome. view more . Credit: Jiangfeng Zhao/EMBL, Daniela Velasco/EMBL. In human cells, only a small proportion of the ...

Researchers have revealed the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process.

The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP ...

The two-step process of pre-mRNA splicing is catalyzed by the spliceosome, a dynamic macromolecular machine composed of U1, U2, U5 and U4/U6 snRNPs and many non-snRNP splicing factors (reviewed in ...

Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, discrete particle. Spliceosome ...

A gene implicated in dementia, ALS, and other motor neuron disorders appears to cause mis-splicing of messenger RNA by preventing proper spliceosome assembly ...

Remix Therapeutics (Remix), a clinical-stage biotechnology company developing small molecule therapies to modulate RNA processing and address underlying drivers of disease, today announced the ...

Malfunctions in the spliceosome lead to diseases known as spliceosomopathies, ... The study showed that cells suffering from a defective spliceosomal U5 snRNP ...

Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications. ... Researchers have revealed the ...