Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

During the first step of converting genetic information into functional proteins, cells transcribe the double-stranded helix ...

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago – a project ...

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago -- a project ...

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago – a project ...

The major spliceosome is abundant in cells and has been extensively investigated for more than four decades. Its long-separated twin – the minor spliceosome, is much more scarce and remains enigmatic, ...

eLife Assessment This study provides important insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and ...

The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP ...

Splicing to generate the mature mRNA (e4-e5) is shown in green. Fig. S7. Scatter plot of significant RI and SE events from rMATS analysis of RNA-seq data from TG-treated cells in the presence or ...

Additionally, Remix Therapeutics, in collaboration with Prof. Aaron Hoskins at the University of Wisconsin-Madison, recently published a mechanistic study on human U1 snRNP in Nature Communications.

Key Findings The study from Shandong Agricultural University found that the AtSNU13 protein is crucial for plant immunity by regulating pre-mRNA splicing in defense-related genes Plants lacking ...

During pre-mRNA splicing, DDX23’s ATPase activity is essential for the pre-B to B spliceosome complex transition and for release of U1 snRNP from the 5′ splice site. We show that the RS-like region of ...