In this new study, the researchers reveal the structure of U11 snRNP -- one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

The structure of a cross-exon spliceosome stalled by SSA captures the intron recognition by U2 snRNP. This indicates that early prespliceosomes (E complexes) select introns through a toehold-mediated ...

Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nature Aging , 2022; DOI: 10.1038/s43587-022-00290-0 Cite This Page : ...

In this study, the authors determined the 3D structure of the ubiquitin-like RNA-binding domain of U2 snRNP protein SF3A1 in complex with a stem-loop RNA of U1 snRNP. Crystallography, NMR spectroscopy ...

Ceptur’s use of synthetic oligonucleotides that engage U1 snRNP offers the ability to co-opt this master regulator of the transcriptome to regulate mRNA in a highly targeted fashion.

Figure 1. Structural model of the human tri-snRNP in two different orientations. Left: An overview of the human tri-snRNP, including all RNA/protein components.Right: Rotated view of the model, ...

The aberrancy of U1 small nuclear ribonucleoprotein (snRNP) complex and RNA splicing has been demonstrated in Alzheimer’s disease (AD). Importantly, the U1 proteopathy is AD-specific, widespread and ...

The human 7SK snRNA is an abundant RNA polymerase III (RNAPIII)‐transcribed nucleoplasmic RNA (Diribarne & Bensaude, 2009).Together with Larp7 (La‐related protein 7) and MePCE (methylphosphate capping ...

Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses ...

U1 snRNP binds to the 5′ exon-intron junction of pre-mRNA and thus plays a crucial role at an early stage of pre-mRNA splicing. We present two crystal structures of engineered U1 sub-structures, which ...