The journey from gene to protein is complex and tightly controlled within each cell. It consists of two major steps: transcription and translation. Here, we describe the processes of transcription and ...

Professor Vlad Pena's group focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced conditions. X. Donate. ... Strand displacement is primarily known ...

Argonaute family members are effectors in small RNA-mediated silencing. In vitro analysis of the four human Argonautes demonstrates that AGO1 and AGO2 mediate multiple rounds of microRNA strand ...

‘Pre-mRNA trans-splicing’ drugs could offer an alternative to gene replacement therapies for genetic diseases ... transcriptional machinery reads DNA and churns out a pre-mRNA strand.

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing -- a critical step in the earliest stage of protein production.

Splicing is closely linked with transcription, involving a dynamic interaction between the mRNA, RNA polymerase II (Pol II), and chromatin structures. 5 “There's strong evidence that splicing of ...

Cambridge-based Strand Therapeutics has a long road ahead to the marketplace. But its path shines a light on the future of health care innovation.

The journey from gene to protein is complex and tightly controlled within each cell. It consists of two major steps: transcription and translation. Here, we describe the processes of transcription and ...

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production.