Now, researchers from Kyushu University have revealed that the smallest known protein-based tRNA-processing enzyme, called ...

When these pre-mRNA sequences undergo constitutive splicing, the removal of introns is followed by the joining of exons in their DNA-corresponding order. Alternative splicing deviates from this ...

(a) Design of an artificial guide RNA (Act-BP-guide) targeting ACT1 pre-mRNA for 2′-O-methylation. Only the guide sequence is shown. Box C, box D and the terminal stem of Act-BP-guide as well as ...

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where ...

Professor Vlad Pena's group focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced ... (see SF3B-PB, SF3B-SSA, SF3B-SUD). Our structures explain why ...

An mRNA vaccine with coding sequences for the pre-fusion protein of RSV is in phase 3 trials for approval for vaccination in patients aged 60 years and older. It shows high effectiveness even in ...

As scientists develop and manufacture novel mRNA therapeutics, they must find technologies that help analyze their drug products on a large scale. Direct mRNA sequence mapping with mass spectrometry ...