What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Leftover drops in vials of Moderna’s COVID-19 vaccine allowed a group of researchers from Stanford University to determine the sequence of the mRNA for SARS-CoV-2’s spike protein that is used in the ...

They had already identified sequences in the pre-mRNA in the EDA neighborhood necessary for regulated splicing, as well as the SR proteins that bind. Through additional experiments they fleshed ...

By delivering mRNA encoding the correct protein sequence into cells, it is possible to restore the production of functional proteins and alleviate disease symptoms. This approach has shown promise in ...

InDevR partners with Aldevron to describe how the VaxArray 5′CapQ assay can be used to measure intact mRNA in a single assay to streamline bioprocess development.

2005-2010: Improvements in mRNA synthesis, purification, and stability through chemical modifications and sequence optimization. 2010-2015: Development of lipid nanoparticle delivery systems for ...

In contrast, in eukaryotic genes, the primary RNA transcript, known as pre-mRNA ... Shine-Dalgarno sequence and the 16S rRNA helps position the ribosome correctly on the mRNA, ensuring accurate ...