What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms.

The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs) are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process by which introns are ...

When these pre-mRNA sequences undergo constitutive splicing, the removal of introns is followed by the joining of exons in their DNA-corresponding order. Alternative splicing deviates from this ...

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing -- a critical step in the earliest stage of protein production.

Once the oligonucleotide drug has bound to its complementary mRNA or pre-mRNA, a series of events ensues. The outcomes depend partly on the nature of the targeted sequence and include destruction ...

Here, we focus specifically on transcription that leads to pre-mRNA, mRNA and eventually proteins. In the process of gene expression, transcription involves the production of ... The mRNA that is ...

In the first paper, published in the Jan. 17 issue of the Cell Systems journal, researchers focused on different mRNA sequences’ affinities for ribosomes, the macromolecules that synthesize proteins ...

On Jan. 10, 2020, when Chinese scientists posted online the genetic sequence for SARS-CoV-2, scientists at the National Institutes of Health (NIH) and the University of Texas-Austin knew by the ...

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where ...

An mRNA vaccine with coding sequences for the pre-fusion protein of RSV is in phase 3 trials for approval for vaccination in patients aged 60 years and older. It shows high effectiveness even in ...

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production.