What's the difference between mRNA and pre-mRNA ... because nearly all eukaryotes have introns and share mechanisms of RNA splicing, splicing itself must be quite ancient. Proponents of the ...

Mechanisms of alternative splicing regulation ... Cell signalling and the control of pre-mRNA splicing. Nature Reviews Molecular Cell Biology 5, 727–738 (2004) doi:10.1038/nrm1467.

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

The results of this work reveal how an alternative splicing mechanism regulates an essential factor for neuronal identity.

is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions. Faulty functioning of a spliceosome can lead to a ...

Researchers have rallied behind mechanisms such as alternative splicing, which may allow a lowly 30,000-gene genome to produce the dizzying variety of proteins that some believe is necessary to ...

They succeeded once they were able to isolate the splicing complexes of the fungus that were in the midst of quality control ...

RNA cleavage can occur either: (i) by a transesterification mechanism that yields 2’,3’-cyclic-PO ... pathways involving the repair of tRNA breaks (during tRNA splicing) and mRNA breaks (during the ...

The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. Alternative RNA splicing functions ...

The mechanisms and physiological consequences of alternative ... transitions via alternative splicing do not show substantial changes in mRNA levels indicating that alternative splicing produces ...