Most interestingly, before the identification of isoginkgetin as a spliceosome inhibitor, two other compounds, pladienolide 6 and FR901464 (ref. 7), were found to inhibit pre-mRNA splicing by ...

RNA splicing articles from across Nature Portfolio RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to ...

Yet, the remaining challenge toward optimizing PM-based mRNA delivery systems for systemic application is to build a functionality to prevent RNase invasion into the polyplex core storing cargo mRNA.