A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

The researchers now plan to further analyze the structures formed by the interactions of Luc7 proteins with mRNA and the rest of the spliceosome, which could help them figure out in more detail ...

helping to make sense of the fragmented messages stored in pre-mRNA. Most genes have many introns that belong to one class—the major introns—which are removed by the major spliceosome.

The researchers now plan to further analyze the structures formed by the interactions of Luc7 proteins with mRNA and the rest of the spliceosome, which could help them figure out in more detail ...

Plants survive cold by adjusting at cellular level. Scientists discovered that the PORCUPINE protein helps plants adapt to ...

Proper splicing requires efficient spliceosome assembly ... Ribosome ubiquitination regulates HAC1 mRNA processing during the unfolded protein response. Here, the authors show that the SCFGrr1 ...

After DNA is copied into messenger RNA (mRNA), noncoding parts called introns are removed, and the coding parts are spliced together. This process is managed by a complex called the spliceosome. MIT ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...